Table 5.
Model performance after the addition of SIRI to the GRACE risk score for predicting clinical outcomes.
| MACE |
Death |
Death + MI |
||||
|---|---|---|---|---|---|---|
| GRACE | GRACE + SIRI | GRACE | GRACE + SIRI | GRACE | GRACE + SIRI | |
| Discrimination | ||||||
| C-statistic | 0.527 | 0.601 | 0.681 | 0.742 | 0.613 | 0.688 |
| p-Value | <.001 | <.001 | <.001 | |||
| IDI (95% CI) | 0.007 (0.001 to 0.020) | −0.001 (−0.002 to 0.004) | 0.189 (0.074 to 0.292) | |||
| p-Value | .040 | .851 | <.001 | |||
| NRI (95% CI) | 0.175 (0.027 to 0.215) | −0.001 (−0.002 to 0.004) | −0.001 (−0.001 to 0.012) | |||
| p-Value | .020 | .059 | .119 | |||
| Calibration | ||||||
| LR test, p-value | <.001 | .018 | <.001 | |||
| AIC | 5195 | 5179 | 661 | 658 | 1307 | 1296 |
| BIC | 5199 | 5188 | 663 | 661 | 1309 | 1301 |
MACE: major adverse cardiovascular events; GRACE: Global registry of acute coronary events; MI: myocardial infarction; IDI: integrated discrimination improvement; NRI: net reclassification improvement; LR: likelihood ratio; AIC: Akaike information criterion; BIC: Bayesian information criterion.