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Independent variables’ levels and responses’ constraints used in the central composite design for the optimization of RLX-PL-MEL nanovesicles.
| Independent variables | Levels |
||
|---|---|---|---|
| (–1) | (0) | (+1) | |
| X1: PL concentration (mg/mL) | 20 | 40 | 60 |
| X2: MEL concentration (mg/mL) | 5 | 10 | 15 |
| Responses | Desirability constraint |
|---|---|
| Y1: particle size (nm) | Minimize |
| Y2: Zeta potential (mV) | Maximize |
| Y3: entrapment efficiency (%) | Maximize |
RLX: raloxifene; PL: phospholipid; MEL: melittin.
