Table 2.

Combination of independent variables in RLX-PL-MEL nanovesicles experimental runs and their corresponding measured responses.

Run	PL concentration (X1, mg/mL)	MEL concentration (X2, mg/mL)	Particle size (Y1, nm)	Zeta potential (Y2, mV)	Entrapment efficiency (Y3, %)
1	40	10	243	–10.6	78.7
2	60	5	275	–19.3	84.6
3	40	10	241	–9.9	77.7
4	20	10	175	–1.4	73.7
5	20	15	188	3.1	74.7
6	40	10	239	–10.9	76.8
7	20	5	156	–4.6	74.6
8	40	10	242	–10.3	77.5
9	60	15	319	–14.1	88.8
10	40	5	216	–12.8	74.8
11	60	10	298	–16.5	87.4
12	40	10	244	–9.7	77.4
13	40	15	265	–8.1	76.9

RLX: raloxifene; PL: phospholipid; MEL: melittin.