Table 2.
Inhibitory effects of compounds 1–6 on the activity of SrtA enzyme and bacterial growth of S. mutans strain OMZ65
| Compound | SrtA IC50 (μM) | pIC50* | MIC (μM)** |
|---|---|---|---|
| 1 | 16.1 | 4.79 | >300 |
| 2 | >300 | - | >300 |
| 3 | 185.3 | 3.7 | >300 |
| 4 | 151.4 | 3.81 | >300 |
| 5 | 51.7 | 4.29 | >300 |
| 6 | 62.5 | 4.20 | 256.9 |
| Triphasiol | 25.3 | 4.60 | ND*** |
| Ampicillin | ND | - | 0.4 |
*pIC50 = −log10(IC50). **MIC means minimum inhibitory concentration. *** ND means not determined. Triphasiol and ampicillin were used as a reference inhibitor of SrtA and a standard of antibacterial drug, respectively.