Table 1.
Comparison of laboratory findings in patients with the initial and the second (meningoencephalitic) phase of tick-borne encephalitis.
| Parameter | Initial phasea | Second phaseb | P value |
|---|---|---|---|
| Leukocytes (× 109/L) | 2.30 (1.20) | 9.30 (3.80) | <0.001 |
| <4 × 109/L | 76/86 (88.4, 79.7–94.3) | 0/87 (0, 0–4.2) | <0.001 |
| Neutrophils (× 109/L) | 1.17 (0.81) | 7.00 (3.09) | <0.001 |
| <1.5 × 109/L | 49/74 (66.2, 54.3–76.8) | 0/86 (0, 0–4.2) | <0.001 |
| Lymphocytes (× 109/L) | 0.80 (0.50) | 1.50 (0.80) | <0.001 |
| <1.1 × 109/L | 56/74 (75.7, 64.3–84.9) | 0/85 (0, 0–4.3) | <0.001 |
| Monocytes (× 109/L) | 0.28 (0.20) | 0.70 (0.40) | <0.001 |
| <0.21 × 109/L | 32/74 (43.2, 31.8–55.3) | 1/85 (1.2, 0–6.4) | <0.001 |
| Thrombocytes (× 109/L) | 132 (49.0) | 249 (108) | <0.001 |
| <150 × 109/L | 55/86 (64.0, 52.9–74.0) | 5/87 (5.7, 1.9–5.9) | <0.001 |
| CRP (mg/L) | 5.00 (2.00) | 5.00 (4.00) | 0.006 |
| ≥5 mg/L | 13/86 (15.1, 8.3–24.5) | 28/86 (32.6, 22.8–43.5) | 0.012 |
| AST (µkat/L) | 0.60 (0.36) | 0.33 (0.14) | <0.001 |
| ≥0.53 µkat/L | 42/70 (0.60, 47.6–71.5) | 13/73 (17.8, 9.8–28.5) | <0.001 |
| ALT (µkat/L) | 0.52 (0.39) | 0.48 (0.34) | 0.583 |
| ≥0.58 µkat/L | 28/70 (0.40, 28.5–52.4) | 25/73 (34.2, 23.5–46.3) | 0.590 |
| GGT (µkat/L) | 0.36 (0.30) | 0.57 (0.52) | <0.001 |
| ≥0.64 µkat/L | 16/69 (23.2, 13.9–34.9) | 31/73 (42.5, 31.0–54.6) | 0.024 |
Data are given as median (interquartile range) or proportion (%, 95% confidence interval). CRP, C-reactive protein; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma-glutamyl transferase.
a
Median duration of illness 5 days, range 1–10 days.
b
Median duration of meningoencephalitic phase of illness 2 days, range 1–10. Median symptom-free interval 8 days.