Table 1.
The detailed information of identified SNPs in exposure and outcomes.
| SNP |
Exposure (Childhood Obesity) |
Primary Outcome (Osteoarthritis) |
Secondary Outcome (Knee Osteoarthritis) |
Secondary Outcome (Hip Osteoarthritis) |
F | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RS ID | Chromosome | Position | EA | OA | Beta | Se | p-Value | EAF | Beta | Se | p-Value | EAF | Beta | Se | p-Value | EAF | Beta | Se | p-Value | EAF | |
| rs10913469 | 1 | 177913519 | C | T | 0.1773 | 0.0330 | 7.99E-08 | NA | 0.0016 | 0.0007 | 2.10E-02 | 0.204573 | 0.0364 | 0.0115 | 1.53E-03 | 0.2061 | 0.0325 | 0.0144 | 2.42E-02 | 0.206 | 14.95681884 |
| rs13130484 | 4 | 45175691 | T | C | 0.1434 | 0.0272 | 1.30E-07 | NA | 0.0011 | 0.0006 | 5.90E-02 | 0.433632 | 0.0124 | 0.0094 | 1.87E-01 | 0.4344 | 0.0072 | 0.0118 | 5.40E-01 | 0.435 | 22.24119754 |
| rs17697518 | 18 | 38765659 | T | C | 0.1855 | 0.0389 | 1.85E-06 | NA | 0.0004 | 0.0009 | 6.00E-01 | 0.127075 | 0.018 | 0.0139 | 1.95E-01 | 0.1277 | −0.0103 | 0.0175 | 5.55E-01 | 0.1274 | 8.982757484 |
| rs256335 | 19 | 34315896 | T | C | 0.1214 | 0.0262 | 3.72E-06 | NA | 0.0014 | 0.0006 | 1.80E-02 | 0.468476 | 0.0066 | 0.0093 | 4.81E-01 | 0.4681 | 0.0057 | 0.0117 | 6.24E-01 | 0.4682 | 19.76190384 |
| rs28636 | 5 | 66149113 | T | C | −0.1474 | 0.0316 | 3.07E-06 | NA | −0.0010 | 0.0007 | 1.50E-01 | 0.22 | −0.0061 | 0.0112 | 5.84E-01 | 0.2208 | −0.0107 | 0.0141 | 4.47E-01 | 0.2209 | 13.65253784 |
| rs4833407 | 4 | 113311790 | A | C | 0.1226 | 0.0265 | 3.88E-06 | NA | 0.0005 | 0.0006 | 3.60E-01 | 0.403415 | 0.0096 | 0.0095 | 3.08E-01 | 0.4029 | 0.0034 | 0.0119 | 7.73E-01 | 0.4038 | 19.05791264 |
| rs4854344 | 2 | 638144 | T | G | 0.2445 | 0.0351 | 3.22E-12 | NA | 0.0026 | 0.0008 | 5.20E-04 | 0.827819 | 0.023 | 0.0123 | 6.17E-02 | 0.8287 | 0.0268 | 0.0155 | 8.26E-02 | 0.829 | 16.90468749 |
| rs4864201 | 4 | 130731284 | C | T | −0.1355 | 0.0281 | 1.41E-06 | NA | −0.0016 | 0.0006 | 6.40E-03 | 0.650954 | −0.0197 | 0.0097 | 4.26E-02 | 0.6534 | 0.0063 | 0.0122 | 6.06E-01 | 0.6539 | 18.70192717 |
| rs571312 | 18 | 57839769 | A | C | 0.1986 | 0.0309 | 1.25E-10 | NA | 0.0018 | 0.0007 | 9.20E-03 | 0.233489 | 0.0305 | 0.011 | 5.38E-03 | 0.2334 | 0.0503 | 0.0137 | 2.50E-04 | 0.2342 | 19.71414151 |
| rs6752378 | 2 | 25150116 | A | C | 0.1695 | 0.0262 | 1.05E-10 | NA | 0.0014 | 0.0006 | 1.80E-02 | 0.486255 | −0.0221 | 0.0093 | 1.75E-02 | 0.4869 | 0.0162 | 0.0117 | 1.64E-01 | 0.4879 | 27.90849147 |
| rs7138803 | 12 | 50247468 | A | G | 0.1672 | 0.0271 | 6.50E-10 | NA | 0.0013 | 0.0006 | 2.60E-02 | 0.369175 | 0.0111 | 0.0096 | 2.50E-01 | 0.3683 | 0.0505 | 0.0121 | 2.85E-05 | 0.3686 | 24.71880986 |
| rs9299 | 17 | 46669430 | T | C | 0.1343 | 0.0282 | 1.91E-06 | NA | 0.0005 | 0.0006 | 4.10E-01 | 0.656465 | 0.0132 | 0.0098 | 1.75E-01 | 0.6574 | 0.0331 | 0.0123 | 6.96E-03 | 0.6579 | 18.3504962 |
| rs9568856 | 13 | 54064981 | A | G | 0.1909 | 0.0395 | 1.36E-06 | NA | 0.0003 | 0.0009 | 7.30E-01 | 0.128121 | 0.0095 | 0.0139 | 4.95E-01 | 0.1276 | 0.0121 | 0.0174 | 4.85E-01 | 0.128 | 9.136671867 |
| rs9941349 | 16 | 53825488 | T | C | 0.1978 | 0.0267 | 1.16E-13 | NA | 0.0011 | 0.0006 | 5.40E-02 | 0.41273 | 0.044 | 0.0094 | 3.00E-06 | 0.4123 | 0.0499 | 0.0118 | 2.44E-05 | 0.4126 | 31.09879584 |
EA: effect allele; OA: other allele; EAF: NA: not applicable.