Table 2.
Sensitivity analysis of primary and secondary MR analyses.
| Outcome | Number of IVs | Heterogeneity test |
MR-Egger pleiotropy test |
MR-PRESSO global pleiotropy test |
||||
|---|---|---|---|---|---|---|---|---|
| Q | p-Value | Intercept | p-Value | RSSobs | p-Value | Outliers | ||
| Primary Outcome (Osteoarthritis) |
14 | 7.6961 | .8628 | −0.000111772 | .8995 | 8.844354 | .908 | None |
| Secondary Outcome (Knee Osteoarthritis) |
12 | 30.0517 | .0046 | −0.01637855 | .4660 | 7.037842 | .911 | rs6752378, rs9941349 |
| Secondary Outcome (Hip Osteoarthritis) |
13 | 26.7515 | .0135 | −0.03142383 | .2287 | 26.52378 | .057 | rs9941349 |
IVs: instrumental variables.