Table 4.

Indications and susceptible pathogens for third-generation tetracycline-class drugs [9,10,12].

Antibiotic	Indication	Susceptible microorganisms
Tigecycline	Complicated skin and skin structure infection	Escherichia coli, Enterococcus faecalis (vancomycin-susceptible isolates), Staphylococcus aureus (methicillin-susceptible and -resistant isolates), Streptococcus agalactiae, Streptococcus anginosus group (includes S. anginosus, S. intermedius, and S. constellatus), Streptococcus pyogenes, Enterobacter cloacae, Klebsiella pneumoniae, and Bacteroides fragilis
	Community-acquired bacterial pneumonia	Streptococcus pneumoniae (penicillin-susceptible isolates), Haemophilus influenzae (β-lactamase negative isolates), and Legionella pneumophila
	Complicated intra-abdominal infection	Citrobacter freundii, E. cloacae, E. coli, Klebsiella oxytoca, K. pneumoniae, E. faecalis (vancomycin-susceptible isolates), S. aureus (methicillin-susceptible and -resistant isolates), S. anginosus group, B. fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Clostridium perfringens, and Peptostreptococcus micros
Eravacycline	Complicated intra-abdominal infection	E. coli, K. pneumoniae, C. freundii, E. cloacae, K. oxytoca, E. faecalis, Enterococcus faecium, S. aureus, S. anginosus group, C. perfringens, Bacteroides spp, and Parabacteroides distasonis
Omadacycline	Acute bacterial skin and skin structure infection (ABSSSI)	S. aureus (methicillin-susceptible and -resistant isolates), Staphylococcus lugdunensis, S. pyogenes, S. anginosus group, E. faecalis, E. cloacae, and K. pneumoniae
	Community-acquired bacterial pneumonia	S. pneumoniae, S. aureus (methicillin-susceptible isolates), H. influenzae, Haemophilus parainfluenzae, K. pneumoniae, L. pneumophila, Mycoplasma pneumoniae, and Chlamydophila pneumoniae