Table 1.
Amino acid mutations related to fatal outcomes in patients with SFTS.
| Amino acid mutation | Fatal/Total (%) | Univariate regression | Multivariate regression* | |||
|---|---|---|---|---|---|---|
| Wild type | Mutation type | OR (95% CI) | P | OR (95% CI) | p | |
| NS | ||||||
| S207P | 114/718 (15.9) | 24/73 (32.9) | 2.595 (1.531–4.399) | <0.001 | 2.987 (1.699–5.251) | <0.001 |
| I223V | 110/681 (16.2) | 28/107 (26.2) | 1.840 (1.142–2.964) | 0.012 | 2.072 (1.246–3.445) | 0.005 |
| D239E | 127/758 (16.8) | 11/32 (34.4) | 2.603 (1.224–5.532) | 0.013 | 2.626 (1.182–5.836) | 0.018 |
| Q245H | 114/718 (15.9) | 24/73 (32.9) | 2.595 (1.531–4.399) | <0.001 | 2.987 (1.699–5.251) | <0.001 |
| Y249H | 110/681 (16.2) | 28/108 (25.9) | 1.817 (1.128–2.925) | 0.014 | 2.061 (1.240–3.424) | 0.005 |
| Gn | ||||||
| D37G | 110/685 (16.1) | 28/104 (26.9) | 1.926 (1.193–3.109) | 0.007 | 2.139 (1.284–3.562) | 0.004 |
| G114E | 114/716 (15.9) | 24/75 (32.0) | 2.485 (1.470–4.200) | <0.001 | 2.876 (1.641–5.038) | <0.001 |
| T273A | 110/681 (16.2) | 28/109 (25.7) | 1.794 (1.115–2.887) | 0.016 | 1.993 (1.201–3.305) | 0.008 |
| Q341P | 109/681 (16.0) | 29/110 (26.4) | 1.879 (1.173–3.009) | 0.009 | 2.077 (1.257–3.431) | 0.004 |
| K371R | 114/717 (15.9) | 24/74 (32.4) | 2.539 (1.500–4.297) | <0.001 | 2.963 (1.687–5.205) | <0.001 |
| Q394H | 110/684 (16.1) | 28/107 (26.2) | 1.849 (1.148–2.980) | 0.011 | 2.084 (1.253–3.464) | 0.005 |
| I491M | 83/508 (16.3) | 29/116 (25.0) | 1.707 (1.054–2.763) | 0.030 | 1.840 (1.103–3.069) | 0.019 |
| M506V | 111/685 (16.2) | 27/106 (25.5) | 1.767 (1.092–2.862) | 0.021 | 1.983 (1.188–3.312) | 0.009 |
| R525G | 111/681 (16.3) | 27/109 (24.8) | 1.691 (1.046–2.733) | 0.032 | 1.944 (1.165–3.242) | 0.011 |
| Gc | ||||||
| V587I | 114/718 (15.9) | 24/73 (32.9) | 2.595 (1.531–4.399) | <0.001 | 2.987 (1.699–5.251) | <0.001 |
| T960I | 90/553 (16.3) | 24/73 (32.9) | 2.520 (1.471–4.315) | <0.001 | 2.880 (1.620–5.121) | <0.001 |
| S1056F | 112/689 (16.3) | 26/101 (25.7) | 1.786 (1.094–2.915) | 0.020 | 2.034 (1.207–3.428) | 0.008 |
| F1058L | 115/715 (16.1) | 23/76 (30.3) | 2.264 (1.335–3.841) | 0.002 | 2.599 (1.478–4.569) | <0.001 |
| RdRp | ||||||
| Y566F | 110/683 (16.1) | 28/108 (25.9) | 1.823 (1.132–2.935) | 0.013 | 2.068 (1.244–3.436) | 0.005 |
| I651V | 111/688 (16.1) | 27/103 (26.2) | 1.847 (1.138-2.996) | 0.013 | 2.123 (1.269–3.551) | 0.004 |
| R835K | 114/715 (15.9) | 24/76 (31.6) | 2.433 (1.442–4.107) | <0.001 | 2.821 (1.613–4.933) | <0.001 |
| S1038T | 115/718 (16.0) | 23/72 (31.9) | 2.461 (1.443–4.198) | <0.001 | 2.785 (1.577–4.920) | <0.001 |
| T1433A | 114/716 (15.9) | 24/75 (32.0) | 2.485 (1.470–4.200) | <0.001 | 2.847 (1.626–4.987) | <0.001 |
| I1447V | 110/680 (16.2) | 28/111 (25.2) | 1.748 (1.088–2.810) | 0.021 | 1.932 (1.166–3.201) | 0.011 |
| R1684K | 114/717 (15.9) | 24/73 (32.9) | 2.591 (1.528–4.392) | <0.001 | 2.986 (1.699–5.248) | <0.001 |
*Adjusting for age, sex, and hospitalization delay. OR = odds ratio; CI = confidence interval. The amino acid mutations with a frequency less than 2% were not included in the association analysis.