Table 2.
Treatment Outcomes of Children and Adolescents Initiating Antiretroviral Therapy in Central Kenya (2004–2014)
| 36-month follow-up ART outcome |
Total |
LTFU |
Dead |
Censored (Retained) |
|---|---|---|---|---|
| n (%) | 5,182 (100.0) | 1,905 (36.8) | 129 (2.5) | 3,148 (60.7) |
| Age, n (%) | ||||
| 0–4 (n = 1,815) | 1,815 (35.0) | 694 (36.4) | 41 (31.8) | 1,080 (34.3) |
| 5–9 (n = 1,704) | 1,704 (32.9) | 558 (29.3) | 43 (33.3) | 1,103 (35.0) |
| 10–14 (n = 997) | 997 (19.2) | 341 (17.9) | 33 (25.6) | 623 (19.8) |
| 15–19 (n = 666) | 666 (12.9) | 312 (16.4) | 12 (9.3) | 342 (10.9) |
| Sex, n (%) | ||||
| Male (n = 2,453) | 2,453 (47.3) | 817 (42.9) | 75 (58.1) | 1,561 (49.6) |
| Female (n = 2,729) | 2,729 (52.7) | 1,088 (57.1) | 54 (41.9) | 1,587 (50.4) |
| Regimen, n (%) | ||||
| D4T (n = 1,103) | 1,103 (23.6) | 315 (18.7) | 45 (40.2) | 743 (25.8) |
| AZT (n = 1,827) | 1,827 (39.1) | 539 (32.0) | 39 (34.8) | 1,249 (43.4) |
| TDF (n = 239) | 239 (5.1) | 161 (9.5) | 4 (3.6) | 74 (2.6) |
| ABC (n = 1,506) | 1,506 (32.2) | 672 (39.8) | 24 (21.4) | 810 (28.2) |
| WHO Stage, n (%) | ||||
| Stage I (n = 1,050) | 1,050 (21.8) | 478 (27.0) | 9 (7.6) | 563 (19.2) |
| Stage II (n = 1,813) | 1,813 (37.7) | 666 (37.7) | 33 (28.0) | 1,114 (38.1) |
| Stage III (n = 1,694) | 1,694 (35.2) | 535 (30.3) | 58 (49.2) | 1,101 (37.6) |
| Stage IV (n = 256) | 256 (5.3) | 89 (5.0) | 18 (15.3) | 149 (5.1) |
| TB status, n (%) | ||||
| TB status, n (%) | 4,431 (96.4) | 1,592 (94.3) | 85 (74.6) | 2,754 (98.5) |
| No TB signs (n = 4,431) | 42 (0.9) | 17 (1.0) | 11 (9.6) | 14 (0.5) |
| Presumptive TB (n = 42) | 124 (2.7) | 79 (4.7) | 18 (15.8) | 27 (1.0) |
| ART Cohort, n (%) | ||||
| 2004 (n = 36) | 36 (0.7) | 13 (0.7) | 0 (0.0) | 23 (0.7) |
| 2005 (n = 138) | 138 (2.7) | 30 (1.6) | 2 (1.6) | 106 (3.4) |
| 2006 (n = 413) | 413 (8.0) | 82 (4.3) | 11 (8.5) | 320 (10.2) |
| 2007 (n = 608) | 608 (11.7) | 168 (8.8) | 29 (22.5) | 411 (13.1) |
| 2008 (n = 662) | 662 (12.8) | 150 (7.9) | 24 (18.6) | 488 (15.5) |
| 2009 (n = 832) | 832 (16.1) | 188 (9.9) | 27 (20.9) | 617 (19.6) |
| 2010 (n = 641) | 641 (12.4) | 158 (8.3) | 16 (12.4) | 467 (14.8) |
| 2011 (n = 586) | 586 (11.3) | 155 (8.1) | 8 (6.2) | 423 (13.4) |
| 2012 (n = 425) | 425 (8.2) | 132 (6.9) | 7 (5.4) | 286 (9.1) |
| 2013 (n = 368) | 368 (7.1) | 358 (18.8) | 3 (2.3) | 7 (0.2) |
| 2014 (n = 473) | 473 (9.1) | 471 (24.7) | 2 (1.6) | 0 (0.0) |
| Months to event, median (IQI) | 36.00 (20.00; 36.00) | 16.00 (8.00; 25.00) | 4.00 (1.00; 15.00) | 36.00 (36.00; 36.00) |
LTFU, lost to follow-up; IQI, interquartile interval.