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. 2022 Jun 16;2022:3192607. doi: 10.1155/2022/3192607

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Copyright © 2022 Xian Liu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Triptolide downregulates SLC7A11/GPX4 axis by direct binding to SLC7A11. (a) The protein levels of SLC7A11 and GPX4 were measured by Western blots. (b, c) The quantitative analysis of the indicated proteins. (d) The synthesis procedure of biotin-triptolide. (e) Immunoblot with anti-SLC7A11 antibody of protein precipitated by streptavidin beads from AC16 cell lysates in the presence of biotin-triptolide (10 μM), biotin (10 μM) or the combination of triptolide (100 μM), and biotin-triptolide (10 μM). (f) Predicted binding sites of triptolide with SLC7A11. (g) Representations of the predicted binding mode of triptolide with SLC7A11. ns: no significant; ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, ^∗∗∗∗p < 0.0001 vs. the control group.