Table 1.
Patient characteristics for the analyzed FFPE tumor tissue cohorts
| Overall | CIS/T1HG cohort | pure TaHG/papillary T1HG | Mixed TaLG/HG | ||
|---|---|---|---|---|---|
| Patients | 225 | 90 | 53 | 82 | |
| Age (years) | |||||
| median | 72 | 72 | 76 | 68 | |
| range | 37–93 | 44–89 | 37–93 | 44–92 | |
| n (%) | n (%) | n (%) | n (%) | ||
| Gender | |||||
| female | 28 (12.4) | 12 (13.3) | 7 (13.2) | 9 (11.0) | |
| male | 198 (87.6) | 78 (86.7) | 46 (86.8) | 73 (89.0) | |
| Tumor stage | |||||
| Ta/CIS | 93 (41.2) | 45 (50.0) | 11 (20.8) | 37 (45.1) | |
| T1 | 132 (58.4) | 45 (50.0) | 42 (79.2) | 45 (54.9) | |
| Focality | |||||
| unifocal | 71 (31.4) | 19 (21.1) | 19 (35.8) | 32 (39.0) | |
| multifocal | 155 (68.6) | 71 (78.9) | 34 (64.2) | 50 (61.0) | |
| Prior treatment | |||||
| BCG | 7 (3.1) | 6 (6.7) | 1 (1.9) | 0 | |
| MMC | 3 (1.3) | 1 (1.1) | 2 (3.7) | 0 | |
| BCG, MMC | 2 (0.9) | 0 | 2 (3.7) | 0 | |
| none | 133 (58.8) | 82 (91.1) | 46 (85.2) | 5 (6.1) | |
| unknown | 80 (35.4) | 1 (1.1) | 2 (3.7) | 77 (93.9) | |
| Sample source | |||||
| TURBT/biopsy | 226 (100.0) | 90 (100.0) | 53 (100.0) | 82 (100.0) | |
| Cystectomy | 0 | 0 | 0 | 0 |
BCG: Bacillus Calmette-Guérin; MMC: Mitomycin C; TURBT: transurethral resection bladder tumor