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. 2022 Jun 23;12:10641. doi: 10.1038/s41598-022-13835-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Genetic alteration-driven networks. (A) DNA methylation-driven network. (B) Copy number-driven network. (C) Mutation-driven network. (D) Combined genetic alteration-driven network. The node size represents the degree of genes. The green edges represent gene pairs between genetic alteration-driven genes and drug target genes. The red edges represent gene pairs between genetic alteration-driven genes and target genes of breast cancer drugs. The node fill color indicates the genetic alteration and the node edge color corresponds to expression difference.