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. 2022 Jun 23;12:10641. doi: 10.1038/s41598-022-13835-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PRLR-associated functional regulations in the methylation alteration-driven network. (A) PARP1-associated gene pairs (green line) can regulate cell proliferation, apoptosis, T cell inhibition, and the JAK-STAT and PI3K-AKT signaling pathways⁸¹. (B) Genetic alteration and gene expression alteration of genes using UCSC Xena. (C) Spearman’s correlations between of PRLR expression and immune cell levels across human breast cancers. (D) Expression differences of PRLR between responders and non-responders to immunotherapy using TISIDB.