Figure 2:

TOX-related regulatory network in ILC development. The arrow represents a positive (stimulatory) connection. The solid line represents a link based on genetic evidence, mostly whether this linkage is through direct or indirect binding of transcription factors to target genes remains to be determined. The dashed line indicates an association inferred from the literature, but where genetic support is absent or indirect. TOX is required in the development of non-cytotoxic ILCs and LTi cells. NFIL3 may function through the NFIL3-TOX-Id2 axis or bypass TOX to directly function through NFIL3-Id2 axis in the development process. In addition, NFIL3 may also bypass Id2 to function only through NFIL3-TOX axis in this process. Besides, TOX is also important in the development of NK cells. Similarly, NFIL3 may also function through the NFIL3-TOX-Id2 axis, NFIL3-Id2 axis, or NFIL3-TOX axis in the development process. But, TOX and TOX2 can affect the development process by regulating T-bet expression, moreover, TOX can also affect the development process by regulating other TFs expression.