Table 1:

The biological roles of various TOX family members.

Type	Biological role
TOX	1. Regulate the development of CD4+ T cells, innate lymphoid cells (ILCs), and T follicular helper (Tfh) cells2.
	2. Regulate CD8+T cell exhaustion.
	3. Regulate mammalian corticogenesis
	4. Mark the occurrence, diagnosis, and classification of cutaneous T-cell lymphoma (CTCL).
	5. Regulate growth, DNA repair, and genomic instability in T-cell acute lymphoblastic leukemia.
TOX2	1. Regulate normal NK cell development.
	2. Regulate Tfh development.
	3. Regulate CD8+ T cell exhaustion.
TOX3	1. Influences neuronal cells survival.
	2. Influences breast cancer cells survival.
	3. As a prognostic marker and/or therapeutic target against colorectal cancer and lung adenocarcinoma.
TOX4	1. Regulate chromatin structure and cell cycle progression.
	2. Modulate cell fate reprogramming.