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. 2022 Jun 23;7:61. doi: 10.1038/s41541-022-00483-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a–d BALB/cJ mice (n = 10/group) were separated into three different cohorts to assess toxicity. A control group received PBS on day 0, 21, and 42 and was sacrificed on day 72. “Acute” and “chronic” cohorts received Ad-GUCY2C (Ad5.F35) on day 0 and Lm-GUCY2C on days 21 and 42 and were sacrificed on days 49 and 72, respectively. Survival (b) and body weight (c) were monitored throughout the study and demonstrated no change from control. d Organs from mice were collected, fixed in formalin, and paraffin embedded. Slides were cut, H&E stained, and scored by a blinded pathologist. Survival (b) was analyzed by the Mantel-Cox log rank. Body weights (c) were analyzed by two-way ANOVA (no significant difference between groups). Histology (d) was analyzed by one-way ANOVA. Error bars indicate mean +/− SEM.