Fig. 2. In vitro validation of aptamers binding affinity.

a Binding response curve for the interaction between RRM1-2 and Apt-1. b Binding response curve for the interaction between RRM1-2 and negative RNA (antisense Apt-1). c Experimental K_d and Protein Fitness scores are tightly anti-correlated (Pearson correlation of −0.93). The experimental values are reported in Table 1. Source data are provided as a Source data file⁶⁴.