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. 2022 Feb 17;13(7):540–547. doi: 10.1007/s13238-021-00904-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Antigen-presenting B cells play a dominant role in antigen presentation in HHcy-accelerated atherosclerosis. (A) tSNE plots showing color-coded cell clusters in the three groups. (B) tSNE plots displaying eight distinct B cell clusters. (C) Bar charts showing the percentages of B cell clusters in the three groups. (D) GO enrichment analyses of biological processes in cluster 0’. (E) Violin plots showing the scaled expression scores (Z-scores) of MHCII-related genes (H2-Aa, H2-Eb1, H2-Ab1, H2-Ob, H2-Eb2, H2-Oa, H2-DMb2, Ctss, Cd74, H2-DMa, and Ctse) across the three groups. (F) Flow cytometry analyses showing the levels of MHCII in CD19⁺ B cells from atherosclerotic aortas. (G–I) Circle plots showing MHCII signaling pathway in the three groups. Data represent mean ± SEM (n = 4 in (F)). * P < 0.05 by an unpaired 2-tailed t test (F).