Fig. 3.
CA does not impair the thrombolytic activity of t-PA. A Experimental design. Drugs were given intravenously at a dose of 0.1 mg/kg for ceruletide and 60 mg/kg for alpha-1 antitrypsin. B Infarct volumes (mm3) of animals treated with vehicle (vehicle, n = 10), t-PA (n = 11), and t-PA together with ceruletide + alpha-1 antitrypsin (tPA + CA, n = 9) 24 h after cerebral ischemia. C Grip strength test measurements performed before MCAO and 24, 48, and 72 h after surgery. Histograms represent strength of both forepaws. Data was assessed in grams. D Representation of the clot formation and lysis experiment showing the two time-points of drug administration: t0 and t1. E Clot formation rate when drugs were added at t0. F Clot formation rate when drugs were added at t1. G Clot area and H clot lysis rate parameters of the experiments performed when drugs were added at t1. In all cases, mean ± SD is shown. * indicates p < 0.05 and #p < 0.1