Fig. 4.

SR8278 microinjection to VTA altered enrichment of R/N motifs in 6-OHDA-lesioned mice only at dawn. (a) Sequence logos for REV-ERBα and NURR1 binding motifs are depicted [13]. (b) Log2 ratio (observed/expected) of ATAC-seq peaks was analyzed using HOMER. (c) Probability of R/N motifs were calculated using HOMER from called peaks and compared the motif enrichments at the indicated times for each experimental group. For each ATAC-seq data analysis, VTA regions were pooled from five individual mice (n = 5, pooled)