Table 2.
Examples of remote-controllable designer cells
| Inducer | Sensor platform | Processor platform | Therapeutic response | Disease | References |
|---|---|---|---|---|---|
| Light | Human melanopsin | Calcium pathway | GLP1 | T2D* | Ye et al. (2011) |
| Opto-CRAC | Calcium pathway | IL12 and TNFα expression | Cancer | He et al. (2015) | |
| LightOn | Orthogonal pathway | Insulin | T1D** | Wang et al. (2012) | |
| FRL-v2 | Endogenous/orthogonal | GLP1 | T2D | Shao et al. (2017) | |
| Magnetic field | Thermo-sensitive channels (TRPV1) | Calcium pathway | Insulin | T1D | Stanley et al. (2012) |
| Mechanical disturbance | Mechanosensitive ion channels (Piezo1) | Calcium pathway | CAR | Cancer | Pan et al. (2018) |
| Temperature | TRMP8 ion channel | Calcium Pathway |
Insulin, mActRIIBECD-hFc*** |
T1D, Muscle atrophy |
Bai et al. (2019) |
| Electrical stimulation | Voltage gated channels (Cav1.2/Kir2.1) | Calcium pathway | Insulin secretion | T1D | Krawczyk et al. (2020) |
*T2D; type-2 diabetes
**T1D; type-1 diabetes
***mActRIIBECD-hFc; modified, activin type IIB, receptor ligand trap protein