Table 3.

Adjusted hazard ratio for covariates with proportional and linear effects associated with the occurrence of first relapse

	Adjusted HR	95% CI	p value
Group
NTZ	1		0.820
Anti-CD20	1.04	[0.74; 1.46]
Year of treatment initiation	0.89	[0.78; 1.01]	0.081
EDSS
[0.0; 1.5]	1
[2.0; 3.5]	1.35	[0.79; 2.30]	0.271
≥ 4.0	1.71	[1.02; 2.87]	0.041
Not available	1.29	[0.75; 2.21]	0.360

Abbreviations: CI, confidence interval; EDSS, expanded disability status scale; HR, hazard ratio; NTZ, natalizumab