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Tregs control ongoing inflammation by acting on major cells that drive allergic reaction, including antigen presentation cells, Teffs, NKT cells, ILC2s, eosinophils, basophils, and mast cells. Tregs suppress IgE-producing B cells, while induce IgG4-producing B cells and IL-10-producing Bregs, and promote the generation of tolerogenic dendritic cells. APC, antigen presentation cell; EOS, eosinophil; BAS, basophil; MC, mast cell.
