Liponin A4 |
Rats |
p-Akt, Nrf2, and HO-1 expression↑ |
Activate the Akt/Nrf2/HO-1 signaling pathway |
Lu T. et al., 2018
|
Hydrogen sulfide |
Rats |
Decreased release of cytokines TNF-α, IL-1β, IL-6, and HMGB1 in spinal cord microglia |
Activate Nrf2/HO-1 signaling pathway |
Chen et al., 2019
|
Hydrogen sulfide |
Rats |
NQO-1 and HO-1 expression↑ |
NaHS activates the Nrf2 signaling molecule, increases the nuclear translocation of Nrf2, and activates the transcription of downstream target genes |
Xu et al., 2021
|
Aspirin |
Rats |
Nrf2, quinine oxidoreductase 1 and HO-1 expression↑, TNF-α, IL-6 expression↓ |
Activating the Nrf2/HO-1 signaling pathway inhibits the activation and apoptosis of astrocytes after SCI |
Wei et al., 2018
|
Dexmedetomidine |
Rats |
IL-1, IL-6, and TNF↓, MDA activity↓ SOD activity↑, Nrf2, and HO-1↑ |
Activate Nrf2/HO-1 signaling pathway |
Luo et al., 2020
|
Imatinib |
Rats |
IL-6, TNF-α and ROS↓, SOD↑ |
Activate the Nrf2/HO-1 signal pathway |
Liu et al., 2020
|
Zinc |
Rats |
ROS and malondialdehyde↓, SOD activity↑, GSH-Px↑, ROS and malondialdehyde↓, SOD activity↑, GSH-Px↑, Nrf2 and Ho-1↑, nlrp3 expression↓ |
Activates the Nrf2/Ho-1 signal pathway |
Li et al., 2020
|
Lithium |
Rats |
The expression of Nrf2 and HO-1↑ |
Activates the Nrf2/heme oxygenase-1 pathway to exert anti-inflammatory and antioxidant effects |
Zhao et al., 2022
|
Tetramethylpyrazine |
Rats |
The expression of IL-1b, TNF-α, IL-18↓ reduces the permeability of the blood-spinal cord barrier |
Activate Akt/Nrf2/HO-1 signaling pathway |
Wang et al., 2016
|
Probucol |
Rats |
Nrf2, HO-1 and NQO1↑, inflammatory factors, IL-1β, IL-6, and TNF-α↓ |
Activate the Nrf2/ARE signal pathway |
Yamashita and Matsuzawa, 2009
|
Riluzole |
Rats |
The expression of GFAP and NF-H↓ |
Activate the Nrf2/HO-1 signaling pathway |
Zhou et al., 2017
|
Methane-rich saline |
Rats |
HO-1, SOD, catalase and GSH↑, glutathione disulfide, superoxide, hydrogen peroxide, malondialdehyde, 8-hydroxy-2-deoxyguanosine and 3-nitrotyrosine↓ |
Activate Nrf2 signaling pathway |
Zhou et al., 2018
|
Metformin |
Rats |
Nrf2, HO-1, and NQO1↑ |
Activate the Nrf2/ARE signal pathway |
Wu et al., 2021
|
Erythropoietin |
Rats |
Nrf2, NQO1↑, and glutathione transferase activity↑ |
Activate the Nrf2 signal pathway |
Wang et al., 2020
|
Lipopolysaccharide |
Rats |
The expression of Nrf2, p-PI3K/PI3K and p-Akt/Akt↑, nuclear translocation of Nrf2↑ |
Activates the PI3K-Akt-Nrf2 signaling pathway |
Longhi et al., 2011
|
2-(-2-benzofuranyl)-2-imidazoline |
Rats |
Nrf2 and HO-1↑ |
Activate the Nrf2/HO-1 signaling pathway |
Li et al., 2013
|
Morin |
Rats |
Nrf2 and HO-1↑ |
Activate the Nrf2/HO-1 signaling pathway |
Jin H. et al., 2021
|
Valproic acid |
Rats |
Nrf2 and Bcl-2 gene expression↓ |
Improve the motor function of the rat contusion model by changing the Mst1, Bcl-2, and Nrf2 gene expression |
Lin et al., 2019
|
Maltol |
Rats |
Nrf2↑ Pink1/Parkin-mediated mitophagy in PC12 cells↑ |
Activate the Nrf2/Pink1/Parkin Pathway |
Mao et al., 2022
|