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. 2022 Jun 10;13:916512. doi: 10.3389/fimmu.2022.916512

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Copyright © 2022 Drost, Rovas, Osiaevi, Rauen, van der Vlag, Buijsers, Salmenov, Lukasz, Pavenstädt, Linke and Kümpers

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HS fragments in severe COVID-19 may partially block HPSE activity. (A) Scatter dot plot showing regression slopes of HPSE activity vs. HS plasma concentration in healthy subjects (n = 12) and COVID-19 patients (n = 16), respectively. (B) Bar charts showing percentage decrease of HPSE activity with increasing amounts of HS (isolated from bovine kidney) in three independent experiments. For this experiment, recombinant human HPSE was used in a concentration of 150 ng/ml. Data are presented as mean ± SEM.