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. 2022 Jun 10;13:873787. doi: 10.3389/fimmu.2022.873787

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Copyright © 2022 Zhong, Zhang, Hong, Zeng, Chen, Liao, Cai, Xu, Wang, Liu, Tang and Dai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Screening the DEGs between the SLE PBMC versus Control PBMC. (A) Volcano plot showing the DEGs between the PBMC of SLE and control samples based on the metadata set including GSE65391, GSE121239, and GSE61635. Green represented down-regulation, and red represented up-regulation (SLE/Control). (B) The heat map showing the DEGs in each sample of SLE patients and healthy people. “Con” represented control samples, and “SLE” represented SLE patients. (C–E) The GO, (F) KEGG, and (G) DO enrichment analysis of the DEGs. The size of the dots represented the number of genes in each enriched module. The color of the dots represented the q value. (H–I) The GSEA analysis revealing the enriched pathways in the PBMC of SLE and control samples.