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. 2022 Jun 10;50(11):6435–6452. doi: 10.1093/nar/gkac362

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — An antisense PPNA targeting acpP shows antibacterial activity against UPEC 536 at 1× MIC. Bactericidal effects of (KFF)₃K-acpP (red) were determined at 1× MIC (1.25 μM) against UPEC 536 (10⁵ cfu/ml) during a 24 h time course. (KFF)₃K-acpP-scrambled (grey) was used as control PPNA, whereas exposure to an equal volume of water served as additional control (black). After the indicated time points, aliquots of each condition were subjected to (A) spot assays or (B) cfu determination on LB plates to investigate the amount of viable cells. (A) Serial dilutions (10^–1 to 10^–3) were prepared, as indicated on the left. (B) Curves represent the mean of the biological replicates. The experiments were performed twice.