Figure 1.

SARS-CoV-2 variant mutations are predominately localized to the spike glycoprotein. (A) A model of the ancestral SARS-CoV-2 spike glycoprotein (PDB 6VXX) with NTD coloured in green and RBD coloured in light blue. Mutations present in the omicron variant (7QO7) are highlighted in red and insertion in orange. Sequence alignments of NTD and RBD are shown to the right with the same coloring scheme. (B) Structures of E2 (orange, PDB 7N0I) and C2 (turquoise, PDB 7N0R) nanobodies complexed with either the CTD (purple) and NTD (pink) of the nucleocapsid protein. The NTD and CTD of N are coloured in a sequence alignment to the right with mutations present in omicron coloured in red.