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Immunofluorescence staining of naïve or infected brain tissue. K18-hACE2 mice were previously challenged with an ancestral strain of SARS-CoV-2 (hCoV-19/Australia/VIC01/2020). Paraffin embedded sectioned brain tissue was then stained with either C2 Fc or E2 Fc nanobodies (red) & DAPI (blue) to detect N antigen and nucleus, respectively.
