Table 1.
Patient with undetectable 6-TGN despite apparently adequate dose of AZA.
| Month post-Tx | Creatinine (mg/dL) | WBC (mm-3) | MCV (fL) | 6-TGN (pmol/8x108) | 6-MMP (pmol/8x10) | AZA (mg/d) | Allopurinol (mg/d) |
|---|---|---|---|---|---|---|---|
| 0 | 5.0 | 8,300 | 86.5 | – | – | 200 | 0 |
| 1 | 2.4 | 17,300 | 89.7 | – | – | 200 | 0 |
| 2 | 2.1 | 13,070 | 92.3 | – | – | 200 | 0 |
| 3 | 2.1 | 14,680 | 94.8 | < 50 | 717 | 200 | 0 |
| 4 | 1.9 | 10,820 | 98.3 | < 50 | 1062 | 200 | 10 |
| 5 | 2.0 | 7,370 | 102 | 115 | 3678 | 200 | 10 |
| 6 | 1.8 | 6,900 | 100 | 203 | 2210 | 200 | 10 |
| 7 | 1.6 | 6,380 | 105 | 247 | 1759 | 200 | 10 |
| 8 | 1.5 | 5,940 | 108 | - | - | 200 | 10 |
| 9 | – | – | - | - | - | 200 | 10 |
| 10 | 1.5 | 5,300 | 107 | - | - | 200 | 10 |
| 11 | 1.4 | 6,670 | 106 | 288 | 3660 | 200 | 10 |
Tx, transplantation; WBC, white blood cell count; MCV, red cell mean corpuscular volume; 6-TGN, red cell thioguanine nucleotide concentration; AZA, azathioprine dosage per day; -, not measured; 6-TGN < 50, below limit of detection.