Table 2.
Patient with low 6-TGN despite apparently adequate dose of AZA.
| Date | Creatinine(mg/dL) | WBC (mm-3) | MCV(fL) | 6-TGN (pmol/8x108) | 6-MMP (pmol/8x10) | AZA (mg/d) | Allopurinol (mg/d) |
|---|---|---|---|---|---|---|---|
| Aug. 2019 | 1.3 | 9,600 | 92.2 | – | – | 200 | 0 |
| Aug 2020 | 1.4 | 10,700 | 90 | – | – | 200 | 0 |
| Nov. 2020 | 1.6 | 10,200 | 92.0 | 180 | 2630 | 200 | 5 |
| Feb. 2021 | 1.5 | 7,530 | 94.2 | 300 | 2813 | 200 | 5 |
| Apr. 2021 | 1.5 | 7,960 | 98.5 | – | – | 200 | 5 |
| Sep. 2021 | – | 6,920 | 99.1 | 435 | 15299 | 200 | 5 |
| Nov. 2021 | 1.3 | 6,600 | 101 | 570 | 5884 | 100 | 5 |
| Jan. 2022 | 1.4 | 10,670 | 97.4 | 293 | 1298 | 100 | 5 |
WBC, white blood cell count; MCV, red cell mean corpuscular volume; 6-TGN, red cell thioguanine nucleotide concentration; AZA, azathioprine dosage per day; -, not measured.