Table 4.

Simulation results, table values description in the results paragraph.

Model parameter	Baseline (N = 43)		Last 5 years (N = 40)		Medicated only (N = 33)		p
	Simulation	Absolute	Simulation	Absolute	Simulation	Absolute
	output SUM	contribution %	output SUM	contribution %	output SUM	contribution %
	(dimensionless)		(dimensionless)		(dimensionless)
Anxiety	−5,264, 94	4, 6%	−7,695, 29	5, 1%	−2,127, 76	6, 3%	0.111
Depression	−1,468, 65	1, 3%	−1,936, 36	1, 3%	−519, 98	1, 5%	0.345
Sleep inertia	−23,785, 71	20, 7%	−31,467, 42	20, 8%	−7,561, 71	22, 3%	0.48
Work and social	−19,854, 40	17, 3%	−22,906, 08	15, 2%	−2,865, 86	8, 5%	0.004
impairment
Sleepiness	−12,983, 30	11, 3%	−17,127, 30	11, 3%	−3,760, 46	11, 1%	0.028
Fatigue	−5,885, 17	5, 1%	−9,196, 22	6, 1%	−3,168, 03	9, 3%	0.345
Naps	19,689, 76	17, 2%	26,442, 19	17, 5%	5,941, 81	17, 5%	0.028
Nocturnal sleep	17,099, 39	14, 9%	22,418, 76	14, 8%	4,535, 73	13, 4%	0.008
Other psychiatric	−1,502, 53	1, 3%	−1,954, 41	1, 3%	−550, 40	1, 6%	0.345
disorders
Somatic pathologies	−4,773, 05	4, 2%	−5,924, 73	3, 9%	−1,077, 70	3, 2%	0.004
Methylphenidate	1,109, 83	1, 0%	1,768, 80	1, 2%	782, 93	2, 3%	0.421
effect
Modafinil effect	1,254, 81	1, 1%	2,244, 32	1, 5%	1,014, 49	3, 0%	0.5
Sum %		100%		100, 0%		100, 0%

Negative results in the simulation output SUM column indicate a negative effect of the parameter and vice versa. The baseline scenario covers all patients for the entire duration of the disease. The last 5 years scenario focuses on the last 5 years; the number of patients in the cohort is reduced by one because the disease, in that case, lasted only 1 year. The medicated only scenario describes the set of medicated patients in the last 5 years of disease duration, regardless of the length of medication and clinical outcomes.