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. 2022 Jun 23;5(6):e2218172. doi: 10.1001/jamanetworkopen.2022.18172

Table 2. Rate of Misdiagnosis by Site of Infection in the 1477 Study Patients.

Site of infection at ED Misdiagnosed sites (n = 171), No./total No. (%) No. of infections by site of infection at discharge
Respiratory Urogenital Abdominal Skin and soft tissue Bone and joint Intravascular CNS Othera No infection Unidentified
Respiratory 46/657 (7.0) 611 11 6 3 0 0 1 3 15b 7
Urogenital 43/336 (12.8) 9 293 8 3 1 4 2 3 5c 8
Abdominal 30/203 (14.8) 4 10 173 0 0 3 0 1 8d 4
Skin and soft tissue 10/145 (6.9) 1 1 1 135 4 2 0 0 1e 0
Bone and joint 12/38 (31.6) 0 1 0 0 26 0 0 1 10f 0
Intravascular 14/30 (46.7) 1 3 2 1 0 16 0 0 4g 3
CNS 8/21 (38.1) 1 2 0 0 1 1 13 2 1h 0
Othera 8/47 (17.0) 3 1 0 1 0 0 0 39 2i 1

Abbreviations: CNS, central nervous system; ED, emergency department.

a

Other sites of infection (eg, ear, nose, and throat) and viral infection.

b

Pulmonary embolism (n = 2), congestive heart failure (n = 2), carcinoma (n = 2), chemical pneumonia (n = 1), neutropenic fever after chemotherapy (n = 1), fever after radiation therapy (n = 1), absorption fever attributable to hematoma (n = 1), pleural effusion (n = 1), nitrofurantoin-induced acute pulmonary toxicity (n = 1), lytic rib lesion (n = 1), symptoms after thoracic endovascular aortic repair (n = 1), and unexplained syncope (n = 1).

c

Terminal heart failure (n = 1), metastatic malignancy (n = 1), delirium (n = 1), terminal kidney insufficiency (n = 1), and dehydration (n = 1).

d

Hepatic encephalopathy (n = 1), silent jaundice (n = 1), hepatic lymphoma (n = 1), inflammatory bowel disease (n = 1), fever after immunotherapy (n = 1), benign paroxysmal positional vertigo (n = 1), ileus (n = 1), and ischemic colitis (n = 1).

e

Lymphoma (n = 1).

f

Arthrosis (n = 2), muscle complaints (n = 2), tophaceous gout (n = 2), calcium pyrophosphate deposition arthritis (n = 2), psoriatic arthritis (n = 1), and osteoarthritis (n = 1).

g

Disseminated intravascular coagulation in metastatic malignancy (n = 1), portal vein thrombosis (n = 1), mitral valve vegetation without clinical symptoms (n = 1), and suspected endocarditis with negative blood culture.

h

Hepatic encephalopathy (n = 1).

i

Febrile neutropenia in acute myeloblastic leukemia (n = 1) and metastatic malignant neoplasm (n = 1).