The average daily food intake, drinking water intake, and body weight of hyperuricemic rats. The rats were injected with PO and treated with allopurinol (HA; 10 mg/kg b.w.), GM (HM2 and HM4; 200 and 400 mg/kg b.w.), or GP (HP2 and HP4; 200 and 400 mg/kg b.w.), and the (A) average daily food intake, (B) drinking water intake, (C) body weight, and (D) gain of body weight were determined as described in the Materials and Methods. Results are expressed as mean ± S.D. for each group of rats (n = 8). # p < 0.05 compared with normal control (N). * p < 0.05 compared with hyperuricemic control (HC).