Figure 1.

Single intraperitoneal administration of 6 mg/kg of oxaliplatin induced cold and mechanical allodynia in mice (A,B). Cold allodynia was assessed by using acetone drop test (A). Mechanical allodynia was measured by using von Frey filament test (B). Control group received 5% glucose as control. D0; day of oxaliplatin or 5% glucose injection, D2; two days following injection, D4; four days after treatment, and D6; six days after treatment. Data are presented by mean ± standard error of the mean (SEM). Control: n = 6, oxaliplatin: n = 6. * p < 0.05, **** p < 0.0001 vs. Control with two-way ANOVA followed by Sidak’s multiple comparisons test.