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. 2022 Jun 8;15(6):726. doi: 10.3390/ph15060726

Figure 2.

Figure 2

The analgesic effect of intraperitoneal injection of [6]-shogaol in oxaliplatin-induced allodynia in mice (A,B). Behavioral tests were conducted four days after 6 mg/kg of oxaliplatin (i.p.) injection. Cold allodynia (A) was assessed by using acetone drop test and mechanical allodynia (B) was measured by using von Frey filament test. Control group mice were treated with 10% of DMSO. Two different doses of [6]-shogaol was used (1 and 10 mg/kg). Baseline: before the injection of 10% DMSO or [6]-shogaol. +1 h: 1 h after 10% DMSO or [6]-shogaol treatment. +3h: 3 h after injection of 10% DMSO or [6]-shogaol administration. Data are presented by mean ± SEM. Control (OXA + 10% DMSO): n = 6, OXA + [6]-shogaol 1 mg/kg: n = 6, OXA + [6]-shogaol 10 mg/kg: n = 6. ** p < 0.01, **** p < 0.0001 vs. Control with two-way ANOVA followed by Tukey’s multiple comparisons test.