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. 2022 Jun 8;15(6):726. doi: 10.3390/ph15060726

Figure 4.

Figure 4

Intrathecal administration of GABAB receptor antagonist prevented the analgesic effect of [6]-shogaol in oxaliplatin-induced cold (A) and mechanical allodynia (B). CGP 55845 is GABAB receptor antagonist. Cold allodynia was assessed by using acetone drop test (A) and mechanical allodynia was measured by using von Frey filament test (B). All group received oxaliplatin injection four days prior to behavior test. Saline was used as control for CGP 55845. [6]-shogaol was intraperitoneal injected 20 min after intrathecal injection of saline and CGP 55845. Baseline: before injection of saline, CGP 55845, and [6]-shogaol. +One h: 1 h after injection of saline, CGP 55845, and [6]-shogaol. Data are presented by mean ± SEM. OXA + saline: n = 5, OXA + CGP 55845: n = 5, OXA + saline + [6]-shogaol: n = 6, OXA + CGP 55845 + [6]-shogaol: n = 5. *** p < 0.001, **** p < 0.0001 vs. OXA + saline with two-way ANOVA followed by Tukey’s multiple comparisons test.