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. 2022 Jun 8;15(6):726. doi: 10.3390/ph15060726

Figure 5.

Figure 5

Change of GABA concentration after [6]-shogaol and 5-HT receptor antagonists administration in superficial laminae of dorsal horn of lumbar 4 -5 spinal cord segments. The lumbar 4–5 segment of the spinal cord of control, (A) oxaliplatin (OXA), (B) [6]-shogaol, (C) OXA + NAN-190, (D) OXA + MDL-72222, and (E) treated mice were stained with GABA antibodies. After immunohistochemistry GABA (green) was quantified (F). All groups, except control group, received oxaliplatin injection four days prior to the experiments. Control group received 5% glucose. Data are presented by mean ± SEM. Control: n = 5, OXA: n = 6, [6]-shogaol: n = 6, NAN-190: n = 5, MDL-72222: n = 5. ** p < 0.01, *** p < 0.001 vs. Control and #### p < 0.0001 vs. OXA with one-way ANOVA followed by Tukey’s multiple comparisons test.