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. 2022 May 24;10(6):831. doi: 10.3390/vaccines10060831

Figure 1.

Figure 1

M1 macrophages infected with rBCG-LTAK63 display marked upregulation of genes associated with IFN signaling pathway. M1 macrophages from 4 different donors were infected with rBCG-LTAK63, BCG, or Mtb H37Rv, and transcriptomic profiles were determined at 24 h post-infection by dcRT-MLPA. (A) Venn diagram displaying the number of differentially expressed genes (p ˂ 0.05) identified in rBCG-LTAK63- or BCG-infected M1 macrophages (fold change in relation to uninfected M1 macrophages). (B) Heat map showing fold changes in expression profile of the 43 immune-related genes in M1 macrophages in response to infection with rBCG-LTAK63, BCG, or Mtb H37Rv. (C) Differentially expressed genes (p ˂ 0.05) in rBCG-LTAK63-infected M1 macrophages when compared to BCG-infected M1 cells. Statistical significance was determined by paired Student’s t-test. Significant differences were observed as indicated * p ˂ 0.05.