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. 2022 Jun 1;8(3):41. doi: 10.3390/ncrna8030041

Figure 2.

Figure 2

GATA6-AS1 and dynamic loss/gain of TAD boundaries and A/B compartment switching. (A) Fourteen unique possibilities of a genomic site based on whether it was associated with the gain or loss of a TAD boundary during cardiac differentiation stages (ES, MES, CP, and CM). The counts for GATA6-AS1 and the control set of randomized sites annotated as one of these unique possibilities are shown and were compared using the Chi-Square test. p-value < 0.001 is indicated by ***. (B) As in panel (A), 14 unique possibilities of a genomic site based on whether it was associated with switching between the two types of compartments, A and B, during the cardiac differentiation stages (ES, MES, CP, and CM). The counts for GATA6-AS1 and the control set of randomized sites annotated as one of these unique possibilities are shown and were compared using the Chi-Square test. p-value < 0.001 is indicated by ***. (C) Gene ontology analysis of targets of triplex-forming sites of GATA6-AS1. The x-axis and y-axis show the top enriched GO “Biological Process” terms and −log10 p-value (enrichment score), respectively.