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In vitro release kinetic analysis of MET and SIT from the optimized formulation (R4).
| Model | MET r2 (n) |
SIT r2 (n) |
|---|---|---|
| Zero-order model | 0.9269 | 0.128 |
| First-order model | 0.9471 | 0.9765 |
| Higuchi model | 0.7433 | 0.8570 |
| Korsmeyer–Peppas model | 0.9633 (0.321) | 0.8813 (0.419) |
| Hixson–Crowell model | 0.8582 | 0.9747 |
