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Body weights and dimensions of the skin lesions in the experimental groups. (A) Mice body weights, (B) lesion lengths (mm) and (C) lesion widths (mm). Data were the mean ± SD and analyzed using one-way ANOVA, followed by Bonferroni’s pairwise comparison test (p < 0.05). ^: versus the vehicle + empty gel group, *: versus the DMBA + empty gel group, &: versus DMBA + free metformin gel. $: versus DMBA + empty ethosome gel.
