Figure 11.

Liver samples stained with H&E. (A,A*) Liver samples from the vehicle + empty gel group show the normal morphological structure of hepatic parenchyma. (B,B*) DMBA + empty gel samples show mild hepatocellular degenerative changes in the pericentral, as well as periportal, regions, with some mononuclear inflammatory cells infiltrating in the hepatic parenchyma. (C,C*) Samples from the DMBA + free metformin gel group showing little hepatocellular vacuolar degenerative changes with minimal inflammatory cell infiltrate records. (D,D*) Samples from the DMBA + ethosome gel group showing mild records of the hepatocellular degenerative changes with higher records of apparent intact hepatocytes, and mild focal mononuclear inflammatory cell infiltrates accompanied with the mild dilatation of hepatic BVs. (E,E*) Samples from the DMBA + metformin ethosome gel group showing almost apparent intact hepatocytes all over hepatic parenchyma, and the moderate dilation of portal BVs with minor focal perivascular inflammatory cell infiltrates, scale bar = 200 μm (left column) and scale bar = 50 μm (right column).