Table 4.

Experimental groups for the in vivo mouse study.

Group 1	Received vehicle (acetone) and topical empty gel.
Group 2	Received DMBA and topical empty gel.
Group 3	Received DMBA and topical free metformin gel.
Group 4	Received DMBA and topical empty ethosomes gel.
Group 5	Received DMBA and metformin ethosomes gel.