Table 2.
Determinants of CM in the univariate analysis.
| Characteristics | N | OR [95% CI] | p Value |
|---|---|---|---|
| Clinical characteristics | |||
| Age at time of diagnosis (per 1 year increment) | 88 | 0.99 [0.96;1.03] | 0.783 |
| HIV status | 88 | ||
| Negative | Ref. | ||
| Positive | 1.34 [0.13;13.5] | 0.797 | |
| Number of cardiovascular risk factors, (per 1 risk factor increment) | 84 | 1.48 [0.93;2.36] | 0.088 |
| Graft rejection before cryptococcosis | 87 | ||
| No | Ref. | ||
| Yes | 0.44 [0.17;1.17] | 0.102 | |
| Tacrolimus at time of diagnosis | 83 | ||
| No | Ref | ||
| Yes | 1.77 [0.64;4.87] | 0.275 | |
| eGFR (CKD-EPI) at time of diagnosis (per 1 mL/min/1.73 m2 increment) | 85 | 1.01 [0.99;1.03] | 0.504 |
| Time between transplant and diagnosis (per 1 year increment) | 79 | 1.54 [0.33;7.22] | 0.533 |
| Clinical presentation | |||
| ICU hospitalization: | 83 | ||
| No | Ref. | ||
| Yes | 2.21 [0.77;6.36] | 0.131 | |
| Natremia at time of diagnosis (per 1 mmol/l increment) | 69 | 0.71 [0.59;0.85] | <0.001 |
| At least one neurological symptom at time of diagnosis | 86 | ||
| No | Ref. | ||
| Yes | 90.85 [17.56;470.16] | <0.0001 | |
| Fever at time of diagnosis | 84 | ||
| No | Ref | ||
| Yes | 1.69 [0.66;4.35] | 0.272 | |
| Skin lesion | 86 | ||
| No | Ref. | ||
| Yes | 0.31 [0.07;1.23] | 0.094 | |
| Cough/Dyspnea | 86 | ||
| No | Ref. | ||
| Yes | 0.33 [0.11;0.98] | 0.046 | |
| Fungemia | 86 | ||
| No | Ref. | ||
| Yes | 2.87 [1.01;8.17] | 0.041 |
NOTE. CKD-EPI: Chronic Kidney Disease Epidemiology; eGFR: estimated glomerular filtration rate; HIV: human immunodeficiency virus; ICU: intensive care unit; OR: odds ratio. Fungemia refers to bloodstream infection caused by Cryptococcus sp.