TEM examination of the retinas. (A,E) C57BL/6 mice were gavaged saline (100 μL/10 g) for seven days. (B,F) First, C57BL/6 mice were gavaged DMSO (1%) for three days, and then they were subretinally injected 7KCh. After injection, gavaging with DMSO (1%) continued for four days. (C,G) C57BL/6 mice were gavaged saline (100 μL/10 g) for three days, then they were subretinally injected 7KCh. After injection, gavaging with saline (100 μL/10 g) continued for four days. (D,H) C57BL/6 mice were gavaged GW3965 (10 mg/kg) for three days, and then they were subretinally injected 7KCh. After injection, gavaging with GW3965 (10 mg/kg) continued for four days (n = 3). White arrows indicate electron-dense material above the BrM. Yellow arrows indicate undigested POS. (A–D), scale bar 2 μm. (E,F), scale bar 1 μm.