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. 2022 Jun 17;10(6):967. doi: 10.3390/vaccines10060967

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Cellular immune response to wild-type (WT) spike and Delta spike. Spike peptide-specific responses by intracellular cytokine staining assays in CD8+ T cells and CD4+ T cells (a–c) 4 months after vaccination in dialysis patients (●■) or volunteers (●■). Means of CD4 or CD8 % population presenting a response (b,c) are numerically shown. CD4+ (b) CD8+ T cells’ (c) production of IL2, TNFα and IFNγ against WT spike ●● and B.1.617.2 (Delta) ■■. Media backgrounds were subtracted from the specific values. Representative dot blot FACS analysis (a). CD4+ or CD8+ T cells’ response to spike stimulation in PBMCs from dialysis patients compared to the healthy cohort. Additionally, shown are cellular response data from unvaccinated, uninfected individuals, or after infection (convalescent).

Cellular immune response to wild-type (WT) spike and Delta spike. Spike peptide-specific responses by intracellular cytokine staining assays in CD8+ T cells and CD4+ T cells (a–c) 4 months after vaccination in dialysis patients (●■) or volunteers (●■). Means of CD4 or CD8 % population presenting a response (b,c) are numerically shown. CD4+ (b) CD8+ T cells’ (c) production of IL2, TNFα and IFNγ against WT spike ●● and B.1.617.2 (Delta) ■■. Media backgrounds were subtracted from the specific values. Representative dot blot FACS analysis (a). CD4+ or CD8+ T cells’ response to spike stimulation in PBMCs from dialysis patients compared to the healthy cohort. Additionally, shown are cellular response data from unvaccinated, uninfected individuals, or after infection (convalescent).