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. 2022 Jun 1;11(6):641. doi: 10.3390/pathogens11060641

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Capsaicin reduced gastric tissue damage. (A) H. pylori infection causes overall inflammation along with distortion of gastric tissue. Inflammatory changes are represented by black arrows. Capsaicin treatment ameliorates the effects of H. pylori infection significantly. Control gastric tissue at 10× and 20× (left panel-CON). H. pylori treated gastric tissue at 10× and 20× (middle panel-HP) and capsaicin-treated infected gastric tissue (Right panel-HP + Caps) after H. pylori infection in mice. (B) Capsaicin binds strongly to NF-κB promoter binding domain. 3D representation of docking complexes of NF-κB with capsaicin as visualized in BIOVIA discovery studio after docking. Docking was performed using Patchdock and Firedock web servers. (C) 2D representation of docked complexes to show hydrogen bonds and amino acid interactions.