Table 2.

Research of inhaled siRNA formulations for respiratory infections.

Disease	Target	Administration	Delivery System	Ref.
Influenza	Nucleoprotein	Intranasal administration	Chitosan nanoparticles	[31]
Influenza	Nucleoprotein, acidic polymerase	Intranasal administration	Oligofectamine	[32]
H1N1	Nucleoprotein, acidic polymerase	Inhalation	PH-responsive peptides	[33]
RSV	N-protein	Intranasal administration	Naked siRNA	[34]
RSV	RSV-protein	Intranasal administration	Naked siRNA	[35]
RSV	NSP1	Intranasal administration	Chitosan nanoparticles	[36]
Pneumonia	TNF-α	Intratracheal delivery	RC-NCs	[30]
Tuberculosis	TGFβ1	Inhalation	Naked siRNA	[37]
Tuberculosis	XCL1	Oro-tracheal administration	Naked siRNA	[29]

Notes: RC, an inflammation-sheddable, charge-reversal pro-peptide of RAGE-binding peptide (RBP); NCs, nanocomplexes.